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    Evidence to Recommendations for Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis (Tdap) Vaccines in Adolescents and Adults

    Summary

    Question: Should recommendations be changed to allow either tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine or tetanus and diphtheria toxoids (Td) vaccine be used in situations where only Td vaccine is recommended?

    Population: Persons aged ≥7 years who have previously received at least one dose of Tdap vaccine and who are recommended to receive Td for the decennial Td booster, for tetanus prophylaxis in the setting of wound management or for the catch-up immunization schedule

    Intervention: Tdap or Td

    Comparison: Td

    Outcome: Safety and immunogenicity; programmatic considerations, including flexibility for providers and ease of implementation

    Background

    Background: Two Tdap vaccines are licensed for use in the United States.

    Boostrix (GSK) is approved for a single dose in persons ≥10 years. Adacel (Sanofi) is approved for persons 10–64 years. Since 2005, a single

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